Many people struggle to keep their weight in check as they get older. Now new research at Karolinska Institutet in Sweden has uncovered why that is: Lipid turnover in the fat tissue decreases during ageing and makes it easier to gain weight, even if we don’t eat more or exercise less than before. The study is published in the journal Nature Medicine.
The scientists studied the fat cells in 54 men and women over an average period of 13 years. In that time, all subjects, regardless of whether they gained or lost weight, showed decreases in lipid turnover in the fat tissue, that is the rate at which lipid (or fat) in the fat cells is removed and stored. Those who didn’t compensate for that by eating less calories gained weight by an average of 20 percent, according to the study which was done in collaboration with researchers at Uppsala University in Sweden and University of Lyon in France.
The researchers also examined lipid turnover in 41 women who underwent bariatric surgery and how the lipid turnover rate affected their ability to keep the weight off four to seven years after surgery. The result showed that only those who had a low rate before the surgery managed to increase their lipid turnover and maintain their weight loss. The researchers believe these people may have had more room to increase their lipid turnover than those who already had a high-level pre-surgery.
“The results indicate for the first time that processes in our fat tissue regulate changes in body weight during ageing in a way that is independent of other factors,” says Peter Arner, professor at the Department of Medicine in Huddinge at Karolinska Institutet and one of the study’s main authors. “This could open up new ways to treat obesity.”
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